Metal toxicity, graphene oxide and chelators for treatment

I did not die suddenly and unexptected yet, but I feel that the clock is ticking.

As some of you already know the reason why I started this substack was to find a potential "cure" for my main condition chest pain.

To my current, still very limited knowledge, I take the following culprits into account:

1. Various metals such as antimony (found in the Moderna shot), gadolinium etc.

2. Graphene oxide capped with PEG (PEG-GO) via esterification.

3. Agonistic autoantibodies.

I only tackled point 1-2 so far which is hard enough, but not 3 (this will be discussed in a separate article).

Cardiovascular Effects

A number of metallic ions interfere with the normal function of myocardial cells, giving rise to arrhythmias, including ventricular fibrillation. Ventricular fibrillation may be responsible for a fatal outcome in cases of poisoning by antimony, barium, or lithium salts.

In a detailed sum up of performed analyses called "Summary of Preliminary Findings" from June 7, 2022 by a German Working group found that for Spikevax (Moderna) antimony was surprisingly above the limit of detection (LOD) using ICP (inductive coupled plasma).

With regard to the potentially toxic consequences, it is to be noted that the following should be considered as side effects of the pentavalent sodium stibogluconate administered directly into the bloodstream, as it most likely occurs in the valence in Moderna: nausea, vomiting, myalgia, headache, lethargy and ECG changes; with prolonged administration, pneumonia, blood count damage and liver dysfunction are to be noted. When they occur, more serious damage mainly affects the liver and heart. These are all clinical events observed after vaccination.

(source: https://thecovidblog.com/wp-content/uploads/2022/08/Working-Group-Germany-report.pdf)

However, the working group stated that their own findings need to be confirmed by other groups, due to the limited amount of available substance.

On a side note: I suffered from severe vomiting and headache exactly 5 days after the 1st shot of spikevax to the point that I had to get hospitalized. The shot itself was not addressed as the root cause in the medical report, but it's clearly mentioned that I got it 5 days ago, which made me suspicious about a possible correlation. A root cause was not found. It was not the heat, not the food that I ate, but sth. else the doctor was probably only hinting at in a very subtle way by her facial expression when I mentioned Moderna.

With regards to antimony and graphene oxide I was coming up with the theory to combine two chelators: glutathione (IV) with subsequent DMSA intake (capsules).

I will discuss this in detail with my health care practitioner after my 5th CaNa2EDTA infusion treatment.

Some crucial qualities of a chelator:

• appropriate pharmacokinetics;

• high affinity toward the toxic metal;

• low toxicity;

• formation of chelate with rapid elimination (detoxification).

As a rule, the formation of stable complexes results from the interaction of hard bases with hard acids, or soft bases with soft acids (HSAB theory by Pearson)

Example: O2 (hard base) and Fe (II) or Fe (III) (hard acid)

The trivalent iron Fe (III) is classified as a "hard" or oxygen-seeking metal ion. The oxygen in EDTA is a "hard" ligand and therefore EDTA would be the choice for removal of iron (III and II). Moreover, EDTA has 4 carboxyl and 2 aminogroups for binding resulting in very stable metal-EDTA chelate complexes.

Figure 1. metal ion EDTA chelate complex

Now I'm applying the same theory to antimony. Antimony (V) is considered as "soft". A coordination to thiol groups (R-SH) such as in DMSA is preferred, but not glutathione.

Figure 2. Chemical structure of DMSA

Figure 3. Chemical structure of GSH

The problem with glutathione (GSH) is the labile formation of the metal-GSH complex which allows a rapid redistribution of metals like mercury in the body. To solve this problem DMSA should be taken to bind mercury which has been mobilized. Glutathione has the ability to reduce graphene oxide.

Another thought is that DMSA can lead to thiol functionalized graphene oxide (reduced with GSH) via a thiol-ene Michael Addition (click reaction) with a base catalyst (pH > 7). Ignore the ring opening reaction of the epoxide, because it makes this topic too complicated for non-scientists.

Figure 4. GO functionalization with cysteamine (CA) and a base catalyst as an example

(source: https://www.sciencedirect.com/science/article/abs/pii/S245226272100009X)

Assuming that there are also free graphene oxide flakes which are not bound to PEG, a functionalization with thiol groups should render it less toxic, but also make it more biocompatible.  The thiol functionalized graphene oxide itself will then become a quite effective heavy metal chelator as several papers are stating this:

• Superior Heavy Metal Ion Adsorption Capacity in Aqueous Solution by High-Density Thiol-Functionalized Reduced Graphene Oxides

 <https://www.researchgate.net/publication/370669620_Superior_Heavy_Metal_Ion_Adsorption_Capacity_in_Aqueous_Solution_by_High-Density_Thiol-Functionalized_Reduced_Graphene_Oxides>

• Adsorption of Functionalized Thiol-Graphene Oxide for Removal of Mercury from Aqueous Solution

 <https://www.researchgate.net/publication/280534392_Adsorption_of_Functionalized_Thiol-Graphene_Oxide_for_Removal_of_Mercury_from_Aqueous_Solution>

• Synthesis of amine and thiol dual functionalized graphene oxide for aqueous sequestration of lead

 <https://www.researchgate.net/publication/339134365_Synthesis_of_amine_and_thiol_dual_functionalized_graphene_oxide_for_aqueous_sequestration_of_lead>

Again this is just a theory. I thoroughly need to discuss this with my health care practitioner. DMSA intake has some serious risks involved if not done correctly. There are just too many factors to consider. I’ll also recommend you to wait for my result of the metal mobilization test after the 5th CaNA2EDTA infusion. I’m excited to compare the results of the 1st and 5th chelation.

Figure 5. Results of the 1st mobilization test after the first EDTA chelation session.